BAIT

RTN4R

NgR, NgR1, Nogor

reticulon 4 receptor

GO Process (2)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

axonogenesis [ISO]

negative regulation of axonogenesis [TAS]

Gene Ontology Molecular Function

receptor activity [TAS]

Gene Ontology Cellular Component

cell surface [ISO]

endoplasmic reticulum [ISO]

extracellular vesicular exosome [ISO]

growth cone [ISO]

plasma membrane [ISO]

RGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Rattus norvegicus

PREY

FGF1

AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1

fibroblast growth factor 1 (acidic)

GO Process (20)

GO Function (5)

GO Component (4)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

anatomical structure morphogenesis [TAS]

branch elongation involved in ureteric bud branching [IDA]

cellular response to heat [IDA]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]

innate immune response [TAS]

insulin receptor signaling pathway [TAS]

mesonephric epithelium development [IDA]

multicellular organismal development [TAS]

neurotrophin TRK receptor signaling pathway [TAS]

phosphatidylinositol-mediated signaling [TAS]

positive regulation of angiogenesis [IDA]

positive regulation of cell division [IDA]

positive regulation of cell migration [IDA]

positive regulation of cell proliferation [IGI]

positive regulation of cholesterol biosynthetic process [IDA]

positive regulation of intracellular signal transduction [IDA]

positive regulation of transcription from RNA polymerase II promoter [IDA]

signal transduction [NAS]

Gene Ontology Molecular Function

S100 protein binding [IPI]
fibroblast growth factor receptor binding [IPI]
growth factor activity [IDA]
heparin binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

extracellular region [IDA, TAS]

extracellular space [IDA]

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength.

Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y, Yeh HH, Shrager P, Giger RJ

In the mature nervous system, changes in synaptic strength correlate with changes in neuronal structure. Members of the Nogo-66 receptor family have been implicated in regulating neuronal morphology. Nogo-66 receptor 1 (NgR1) supports binding of the myelin inhibitors Nogo-A, MAG (myelin-associated glycoprotein), and OMgp (oligodendrocyte myelin glycoprotein), and is important for growth cone collapse in response to acutely presented inhibitors ... [more]

J. Neurosci. Mar. 12, 2008; 28(11);2753-65 [Pubmed: 18337405]

Throughput

Low Throughput

Curated By

BioGRID