BAIT
AQP2
AQP-CD, WCH-CD
aquaporin 2 (collecting duct)
GO Process (8)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BCAP31
6C6-AG, BAP31, CDM, DDCH, DXS1357E
B-cell receptor-associated protein 31
GO Process (9)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- calcium-mediated signaling using intracellular calcium source [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- negative regulation of endoplasmic reticulum calcium ion concentration [IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial calcium ion concentration [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.
Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2 (AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells. Whereas binding of vasopressin to its type-2 receptor initiates a cAMP-protein kinase A cascade and AQP2 translocation to the apical membrane, this is counteracted by protein kinase C-activating hormones, resulting in ubiquitination-dependent internalization of AQP2. The ... [more]
PLoS ONE Sep. 21, 2017; 12(9);e0183774 [Pubmed: 28931009]
Throughput
- High Throughput
Curated By
- BioGRID