BAIT
AQP2
AQP-CD, WCH-CD
aquaporin 2 (collecting duct)
GO Process (8)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLP2
A4, A4LSB
proteolipid protein 2 (colonic epithelium-enriched)
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.
Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2 (AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells. Whereas binding of vasopressin to its type-2 receptor initiates a cAMP-protein kinase A cascade and AQP2 translocation to the apical membrane, this is counteracted by protein kinase C-activating hormones, resulting in ubiquitination-dependent internalization of AQP2. The ... [more]
PLoS ONE Sep. 21, 2017; 12(9);e0183774 [Pubmed: 28931009]
Throughput
- High Throughput
Curated By
- BioGRID