MTSS1
Gene Ontology Biological Process
- actin filament organization [IDA]
- actin filament polymerization [IDA]
- adherens junction maintenance [IMP]
- bone mineralization [IMP]
- cellular response to fluid shear stress [IDA]
- epithelial cell proliferation involved in renal tubule morphogenesis [IMP]
- glomerulus morphogenesis [IMP]
- in utero embryonic development [IGI]
- magnesium ion homeostasis [IMP]
- muscle organ development [NAS]
- negative regulation of epithelial cell proliferation [IMP]
- nephron tubule epithelial cell differentiation [IMP]
- nervous system development [NAS]
- positive regulation of actin filament bundle assembly [IMP]
- renal system development [IMP]
- renal tubule morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAB7
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- bone resorption [ISO]
- early endosome to late endosome transport [ISO]
- endosome to lysosome transport [IBA, ISO]
- epidermal growth factor catabolic process [ISO]
- intracellular protein transport [TAS]
- phagosome acidification [ISO]
- phagosome-lysosome fusion [IBA, ISO]
- positive regulation of exosomal secretion [ISO]
- protein targeting to lysosome [ISO]
- protein to membrane docking [ISO]
- regulation of autophagic vacuole assembly [ISO]
- retrograde transport, endosome to Golgi [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- alveolar lamellar body [ISO]
- cell [TAS]
- cytoplasm [IDA]
- cytoplasmic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [TAS]
- intracellular membrane-bounded organelle [ISO]
- late endosome [IDA, ISO]
- lysosome [IBA, ISO]
- phagocytic vesicle [IBA, ISO]
- pre-autophagosomal structure membrane [IDA]
- retromer complex [ISO]
- terminal bouton [ISO]
- vacuolar membrane [IBA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases.
Surface expression of chemokine receptor CXCR4 is downregulated by missing-in-metastasis protein (MIM; also known as MTSS1), a member of the inverse BAR (I-BAR)-domain protein family that recognizes and generates membranes with negative curvature. Yet, the mechanism for the regulation is unknown. Here, we show that MIM forms a complex with CXCR4 by binding to E3 ubiquitin ligase AIP4 (also known ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID