KMT2A
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- embryonic hemopoiesis [TAS]
- histone H3-K4 methylation [IDA, IMP]
- histone H3-K4 trimethylation [IDA]
- histone H4-K16 acetylation [IMP]
- positive regulation of cellular response to drug [IMP]
- positive regulation of histone H3-K4 methylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of transporter activity [IMP]
- protein complex assembly [IDA]
- regulation of histone H3-K14 acetylation [ISS]
- regulation of histone H3-K9 acetylation [ISS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
KMT2A
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- embryonic hemopoiesis [TAS]
- histone H3-K4 methylation [IDA, IMP]
- histone H3-K4 trimethylation [IDA]
- histone H4-K16 acetylation [IMP]
- positive regulation of cellular response to drug [IMP]
- positive regulation of histone H3-K4 methylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of transporter activity [IMP]
- protein complex assembly [IDA]
- regulation of histone H3-K14 acetylation [ISS]
- regulation of histone H3-K9 acetylation [ISS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins.
The human ALL-1 gene is involved in acute leukemia through gene fusions, partial tandem duplications or a specific deletion. Several sequence motifs within the ALL-1 protein, such as the SET domain, PHD fingers and the region with homology to DNA methyl transferase are shared with other proteins involved in transcription regulation through chromatin alterations. However, the function of these motifs ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KMT2A KMT2A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KMT2A KMT2A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KMT2A KMT2A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KMT2A KMT2A | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 951024 | |
| KMT2A KMT2A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| KMT2A KMT2A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| KMT2A KMT2A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| KMT2A KMT2A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| KMT2A KMT2A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID