BAIT

HIP1R

AA410023, mKIAA0655
huntingtin interacting protein 1 related
GO Process (1)
GO Function (3)
GO Component (6)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

CLTB

LCB
clathrin, light chain B
GO Process (0)
GO Function (1)
GO Component (4)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.

Wilbur JD, Chen CY, Manalo V, Hwang PK, Fletterick RJ, Brodsky FM

The huntingtin-interacting protein family members (Hip1 and Hip1R in mammals and Sla2p in yeast) link clathrin-mediated membrane traffic to actin cytoskeleton dynamics. Genetic data in yeast have implicated the light chain subunit of clathrin in regulating this link. To test this hypothesis, the biophysical properties of mammalian Hip1 and Hip1R and their interaction with clathrin light chain and actin were ... [more]

J. Biol. Chem. Nov. 21, 2008; 283(47);32870-9 [Pubmed: 18790740]

Throughput

  • Low Throughput

Curated By

  • BioGRID