BAIT
CFTR
ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, tcag7.78
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
GO Process (9)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- cellular response to cAMP [ISS]
- chloride transmembrane transport [IDA, ISS, NAS, TAS]
- intracellular pH elevation [ISS]
- membrane hyperpolarization [ISS]
- positive regulation of voltage-gated chloride channel activity [IDA]
- respiratory gaseous exchange [TAS]
- sperm capacitation [ISS]
- transmembrane transport [TAS]
- transport [TAS]
Gene Ontology Molecular Function- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB14
FBP, RAB-14, RP11-165P4.4
RAB14, member RAS oncogene family
GO Process (12)
GO Function (5)
GO Component (19)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- Golgi to endosome transport [ISS, TAS]
- Rab protein signal transduction [IBA]
- embryo development [ISS]
- endocytic recycling [IDA]
- fibroblast growth factor receptor signaling pathway [ISS]
- intracellular protein transport [IBA]
- intracellular transport [NAS]
- membrane organization [TAS]
- phagolysosome assembly involved in apoptotic cell clearance [IBA]
- regulation of protein localization [IDA]
- vesicle-mediated transport [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IBA]
- Golgi stack [ISS]
- cytoplasmic vesicle membrane [TAS]
- cytosol [ISS]
- early endosome [IBA, ISS]
- extracellular vesicular exosome [IDA]
- intracellular [IDA]
- intracellular membrane-bounded organelle [IDA]
- late endosome [ISS]
- lysosomal membrane [IDA]
- lysosome [ISS]
- nuclear outer membrane-endoplasmic reticulum membrane network [ISS]
- perinuclear region of cytoplasm [ISS]
- phagocytic vesicle [IDA]
- plasma membrane [ISS]
- primary cilium [IDA]
- recycling endosome [IDA]
- rough endoplasmic reticulum [ISS]
- trans-Golgi network transport vesicle [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.
Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (∆F508 CFTR) is the major cause of cystic fibrosis, one of the most common inherited childhood diseases. The mutated CFTR anion channel is not fully glycosylated and shows minimal activity in bronchial epithelial cells of patients with cystic fibrosis. Low temperature or inhibition of histone deacetylases can partly rescue ... [more]
Nature Dec. 24, 2015; 528(7583);510-6 [Pubmed: 26618866]
Throughput
- High Throughput
Additional Notes
- Co-Purifying Protein Identification Technology (CoPIT)
Curated By
- BioGRID