BAIT
GJA1
Cx43
gap junction protein, alpha 1
GO Process (61)
GO Function (10)
GO Component (28)
Gene Ontology Biological Process
- ATP transport [IMP]
- adult heart development [ISO]
- apoptotic process [IMP]
- atrial ventricular junction remodeling [ISO]
- blood vessel morphogenesis [ISO]
- cardiac conduction [ISO]
- cell communication [IMP]
- cell communication by chemical coupling [ISO]
- cell communication by electrical coupling [ISO]
- cell-cell junction organization [ISO]
- cell-cell signaling [IDA, ISO]
- cellular response to mechanical stimulus [IEP]
- chronic inflammatory response [IMP]
- embryonic digit morphogenesis [ISO]
- embryonic heart tube development [ISO]
- endothelium development [IEP]
- epithelial cell maturation [ISO]
- gap junction assembly [TAS]
- heart development [IEP, ISO]
- heart looping [ISO]
- in utero embryonic development [ISO]
- lens development in camera-type eye [ISO]
- milk ejection [ISO]
- negative regulation of DNA biosynthetic process [IDA]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of wound healing [IMP]
- neuron migration [ISO]
- neuron projection morphogenesis [IMP]
- osteoblast differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [IMP]
- positive regulation of cell communication by chemical coupling [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of glomerular filtration [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of protein catabolic process [IDA]
- positive regulation of striated muscle tissue development [ISO]
- positive regulation of vasoconstriction [IMP]
- positive regulation of vasodilation [IMP]
- protein oligomerization [IDA]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of bone mineralization [ISO]
- regulation of bone remodeling [ISO]
- regulation of calcium ion transport [IMP]
- regulation of heart contraction [ISO]
- regulation of tight junction assembly [IMP]
- regulation of ventricular cardiac muscle cell membrane depolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to fluid shear stress [IEP]
- response to glucose [IEP]
- response to pH [IDA]
- response to peptide hormone [IEP]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [ISO]
- transmembrane transport [IDA, ISO]
- vascular transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Golgi membrane [TAS]
- Golgi-associated vesicle membrane [TAS]
- apical plasma membrane [ISO]
- cell junction [ISO]
- cell-cell junction [ISO]
- connexon complex [IDA]
- contractile fiber [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [IDA]
- endoplasmic reticulum membrane [TAS]
- endosome [IDA]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- integral component of plasma membrane [TAS]
- intercalated disc [ISO]
- intermediate filament [ISO]
- late endosome [IDA]
- lateral plasma membrane [ISO]
- lysosome [IDA]
- membrane [IDA, ISO]
- membrane raft [IDA]
- mitochondrial outer membrane [IDA]
- multivesicular body [IDA]
- plasma membrane [IDA, IMP, ISO, TAS]
Rattus norvegicus
PREY
ITGB1
integrin, beta 1
GO Process (58)
GO Function (18)
GO Component (32)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- axon extension [ISO]
- calcium-independent cell-matrix adhesion [ISO]
- cardiac muscle cell differentiation [ISO]
- cardiac muscle tissue development [ISO]
- cell adhesion [IDA]
- cell fate specification [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cell-cell adhesion mediated by integrin [ISO]
- cell-matrix adhesion [ISO]
- cell-substrate adhesion [ISO]
- cellular calcium ion homeostasis [IDA]
- cellular response to ionizing radiation [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to vitamin D [IEP]
- dendrite morphogenesis [ISO]
- formation of radial glial scaffolds [ISO]
- germ cell migration [ISO]
- heterotypic cell-cell adhesion [ISO]
- in utero embryonic development [ISO]
- integrin-mediated signaling pathway [IDA, ISO]
- leukocyte cell-cell adhesion [ISO]
- leukocyte tethering or rolling [ISO]
- maternal process involved in female pregnancy [IEP]
- mesodermal cell differentiation [ISO]
- negative regulation of Rho protein signal transduction [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of cell projection organization [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of neuron differentiation [IMP]
- neuron projection development [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-substrate adhesion [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISO, ISS]
- positive regulation of neuron differentiation [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- protein transport within lipid bilayer [IMP]
- regulation of G-protein coupled receptor protein signaling pathway [IMP]
- regulation of cell cycle [ISO]
- regulation of collagen catabolic process [ISO, ISS]
- response to activity [IEP]
- response to drug [IEP]
- response to gonadotropin [IEP]
- response to nutrient levels [IEP]
- response to transforming growth factor beta [IEP]
- sarcomere organization [ISO]
- stress fiber assembly [ISO]
- tight junction assembly [IMP]
- tissue homeostasis [IMP]
- transforming growth factor beta receptor signaling pathway [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- actin binding [IDA, ISO]
- alpha-actinin binding [IDA]
- cell adhesion molecule binding [ISO]
- collagen binding [IDA]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [IDA]
- glycoprotein binding [IPI]
- integrin binding [IMP, IPI, ISO]
- kinase binding [IPI]
- laminin binding [IDA, IMP, ISO]
- peptide binding [IDA]
- protease binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IDA]
- protein heterodimerization activity [IC, IMP, IPI, ISO]
- protein kinase binding [IPI]
- receptor binding [IPI]
- actin binding [IDA, ISO]
- alpha-actinin binding [IDA]
- cell adhesion molecule binding [ISO]
- collagen binding [IDA]
- collagen binding involved in cell-matrix adhesion [ISO]
- fibronectin binding [IDA]
- glycoprotein binding [IPI]
- integrin binding [IMP, IPI, ISO]
- kinase binding [IPI]
- laminin binding [IDA, IMP, ISO]
- peptide binding [IDA]
- protease binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [IDA]
- protein heterodimerization activity [IC, IMP, IPI, ISO]
- protein kinase binding [IPI]
- receptor binding [IPI]
Gene Ontology Cellular Component
- acrosomal vesicle [IDA]
- adherens junction [IDA]
- basement membrane [IDA]
- cell surface [IDA, ISO]
- cell-cell junction [IDA]
- cytoplasm [ISO]
- dendritic spine [ISO]
- external side of plasma membrane [ISO]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [IDA, ISO]
- hemidesmosome [IDA]
- integrin alpha1-beta1 complex [ISO]
- integrin alpha10-beta1 complex [ISO]
- integrin alpha11-beta1 complex [ISO]
- integrin alpha2-beta1 complex [ISO]
- integrin alpha3-beta1 complex [IDA, ISO]
- integrin alpha7-beta1 complex [ISO]
- integrin alpha9-beta1 complex [IDA]
- integrin complex [IC, IDA]
- intercalated disc [ISO]
- invadopodium membrane [ISO, ISS]
- membrane [IDA, ISO]
- membrane raft [IDA, ISO]
- myelin sheath abaxonal region [ISO]
- neuromuscular junction [ISO]
- plasma membrane [ISO, TAS]
- receptor complex [ISO]
- ruffle membrane [ISO]
- sarcolemma [ISO]
- synapse [ISO]
- synaptic membrane [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart.
The coordinated and synchronized cardiac muscle contraction relies on an efficient gap junction-mediated intercellular communication (GJIC) between cardiomyocytes, which involves the rapid anisotropic impulse propagation through connexin (Cx)-containing channels, namely of Cx43, the most abundant Cx in the heart. Expectedly, disturbing mechanisms that affect channel activity, localization and turnover of Cx43 have been implicated in several cardiomyopathies, such as myocardial ... [more]
Mol. Cell Proteomics Nov. 01, 2015; 14(11);3040-55 [Pubmed: 26316108]
Throughput
- High Throughput
Additional Notes
- Identification of Cx43-binding partners using the SWATH-MS method.
Curated By
- BioGRID