ITCH
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- inflammatory response [NAS]
- innate immune response [TAS]
- negative regulation of JNK cascade [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of defense response to virus [IMP]
- negative regulation of type I interferon production [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- protein K29-linked ubiquitination [IDA]
- protein K48-linked ubiquitination [IDA]
- protein K63-linked ubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of cell growth [NAS]
- regulation of protein deubiquitination [ISS]
- ubiquitin-dependent protein catabolic process [IDA, NAS]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
GRB2
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- aging [IPI]
- anatomical structure formation involved in morphogenesis [ISO]
- branching involved in labyrinthine layer morphogenesis [ISO]
- cell differentiation [ISO]
- cellular response to ionizing radiation [ISO]
- fibroblast growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of signal transduction [ISO]
- protein heterooligomerization [IDA]
- receptor internalization [ISO]
- regulation of MAPK cascade [ISO]
- signal transduction in response to DNA damage [ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- SH3 domain binding [ISO, ISS]
- SH3/SH2 adaptor activity [ISO]
- ephrin receptor binding [ISO]
- epidermal growth factor receptor binding [IPI, ISO, ISS]
- identical protein binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [IPI]
- phosphotyrosine binding [IPI]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI, ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
The ligase Itch plays major roles in signaling pathways by inducing ubiquitylation-dependent degradation of several substrates. Substrate recognition and binding are critical for the regulation of this reaction. Like closely related ligases, Itch can interact with proteins containing a PPXY motif via its WW domains. In addition to these WW domains, Itch possesses a proline-rich region (PRR) that has been ... [more]
Throughput
- High Throughput
Additional Notes
- Hit identified by MS
Curated By
- BioGRID