BAIT
ITCH
ADMFD, AIF4, AIP4, NAPP1, dJ468O1.1
itchy E3 ubiquitin protein ligase
GO Process (19)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- inflammatory response [NAS]
- innate immune response [TAS]
- negative regulation of JNK cascade [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of defense response to virus [IMP]
- negative regulation of type I interferon production [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- protein K29-linked ubiquitination [IDA]
- protein K48-linked ubiquitination [IDA]
- protein K63-linked ubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of cell growth [NAS]
- regulation of protein deubiquitination [ISS]
- ubiquitin-dependent protein catabolic process [IDA, NAS]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PACSIN2
SdpII
protein kinase C and casein kinase substrate in neurons 2
GO Process (8)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- caveola [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- endosome [IBA]
- extracellular vesicular exosome [ISO]
- extrinsic component of membrane [ISO, ISS]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [IBA]
- membrane-bounded vesicle [IBA]
- nucleoplasm [ISO]
- recycling endosome membrane [ISO]
- trans-Golgi network [ISO]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
The ligase Itch plays major roles in signaling pathways by inducing ubiquitylation-dependent degradation of several substrates. Substrate recognition and binding are critical for the regulation of this reaction. Like closely related ligases, Itch can interact with proteins containing a PPXY motif via its WW domains. In addition to these WW domains, Itch possesses a proline-rich region (PRR) that has been ... [more]
J. Biol. Chem. Dec. 14, 2016; 292(15);6325-6338 [Pubmed: 28235806]
Throughput
- High Throughput
Additional Notes
- Hit identified by MS
Curated By
- BioGRID