BAIT
ITCH
ADMFD, AIF4, AIP4, NAPP1, dJ468O1.1
itchy E3 ubiquitin protein ligase
GO Process (19)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- inflammatory response [NAS]
- innate immune response [TAS]
- negative regulation of JNK cascade [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of defense response to virus [IMP]
- negative regulation of type I interferon production [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- protein K29-linked ubiquitination [IDA]
- protein K48-linked ubiquitination [IDA]
- protein K63-linked ubiquitination [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of cell growth [NAS]
- regulation of protein deubiquitination [ISS]
- ubiquitin-dependent protein catabolic process [IDA, NAS]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
SH3GL1
SH3P8
SH3-domain GRB2-like 1
GO Process (0)
GO Function (4)
GO Component (1)
Gene Ontology Molecular Function
Rattus norvegicus
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
The ligase Itch plays major roles in signaling pathways by inducing ubiquitylation-dependent degradation of several substrates. Substrate recognition and binding are critical for the regulation of this reaction. Like closely related ligases, Itch can interact with proteins containing a PPXY motif via its WW domains. In addition to these WW domains, Itch possesses a proline-rich region (PRR) that has been ... [more]
J. Biol. Chem. Dec. 14, 2016; 292(15);6325-6338 [Pubmed: 28235806]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ITCH SH3GL1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | High | - | BioGRID | 2449189 |
Curated By
- BioGRID