APP
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- axon cargo transport [IGI, IMP]
- axon midline choice point recognition [IMP]
- axonogenesis [IMP]
- cellular copper ion homeostasis [IGI, IMP]
- cholesterol metabolic process [IGI, IMP]
- collateral sprouting in absence of injury [IGI]
- dendrite development [IGI, IMP]
- endocytosis [IMP]
- extracellular matrix organization [IGI]
- forebrain development [IMP]
- ionotropic glutamate receptor signaling pathway [IMP]
- locomotory behavior [IGI]
- mRNA polyadenylation [IDA]
- mating behavior [IGI]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of neuron differentiation [IDA, IGI]
- neuromuscular process controlling balance [IGI]
- neuron apoptotic process [IGI, ISO]
- neuron projection development [IDA]
- neuron remodeling [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of peptidase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein homooligomerization [ISO]
- protein phosphorylation [IMP]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of gene expression [IDA]
- regulation of multicellular organism growth [IMP]
- regulation of protein binding [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of translation [IDA]
- response to oxidative stress [IGI]
- smooth endoplasmic reticulum calcium ion homeostasis [IGI]
- suckling behavior [IGI]
- synaptic growth at neuromuscular junction [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [IDA]
- Golgi apparatus [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA, ISO]
- cell [IGI]
- cell surface [ISO]
- cell-cell junction [IDA]
- ciliary rootlet [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IDA]
- intracellular [IGI]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA, TAS]
- membrane raft [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- smooth endoplasmic reticulum [IGI]
- spindle midzone [IDA]
- terminal bouton [ISO]
STUB1
Gene Ontology Biological Process
- cellular response to misfolded protein [IMP, ISO]
- misfolded or incompletely synthesized protein catabolic process [IMP, ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of protein ubiquitination [ISO, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein folding [TAS]
- protein maturation [TAS]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [TAS]
- regulation of glucocorticoid metabolic process [ISO, ISS]
- ubiquitin-dependent SMAD protein catabolic process [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
The amyloid precursor protein (APP), whose mutations cause Alzheimer disease, plays an important in vivo role and facilitates transmitter release. Because the APP cytosolic region (ACR) is essential for these functions, we have characterized its brain interactome. We found that the ACR interacts with proteins that regulate the ubiquitin-proteasome system, predominantly with the E3 ubiquitin-protein ligases Stub1, which binds the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STUB1 APP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| APP STUB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID