BAIT
APP
Abeta, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp
amyloid beta (A4) precursor protein
GO Process (38)
GO Function (10)
GO Component (27)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- axon cargo transport [IGI, IMP]
- axon midline choice point recognition [IMP]
- axonogenesis [IMP]
- cellular copper ion homeostasis [IGI, IMP]
- cholesterol metabolic process [IGI, IMP]
- collateral sprouting in absence of injury [IGI]
- dendrite development [IGI, IMP]
- endocytosis [IMP]
- extracellular matrix organization [IGI]
- forebrain development [IMP]
- ionotropic glutamate receptor signaling pathway [IMP]
- locomotory behavior [IGI]
- mRNA polyadenylation [IDA]
- mating behavior [IGI]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of neuron differentiation [IDA, IGI]
- neuromuscular process controlling balance [IGI]
- neuron apoptotic process [IGI, ISO]
- neuron projection development [IDA]
- neuron remodeling [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of peptidase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein homooligomerization [ISO]
- protein phosphorylation [IMP]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of gene expression [IDA]
- regulation of multicellular organism growth [IMP]
- regulation of protein binding [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of translation [IDA]
- response to oxidative stress [IGI]
- smooth endoplasmic reticulum calcium ion homeostasis [IGI]
- suckling behavior [IGI]
- synaptic growth at neuromuscular junction [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [IDA]
- Golgi apparatus [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA, ISO]
- cell [IGI]
- cell surface [ISO]
- cell-cell junction [IDA]
- ciliary rootlet [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IDA]
- intracellular [IGI]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA, TAS]
- membrane raft [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- smooth endoplasmic reticulum [IGI]
- spindle midzone [IDA]
- terminal bouton [ISO]
Mus musculus
PREY
SYT1
AW124717, G630098F17Rik, SytI
synaptotagmin I
GO Process (9)
GO Function (15)
GO Component (13)
Gene Ontology Biological Process
- detection of calcium ion [ISO]
- neurotransmitter secretion [IDA]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of vesicle fusion [ISO]
- regulation of calcium ion-dependent exocytosis [ISO]
- regulation of regulated secretory pathway [ISO]
- response to calcium ion [ISO]
- synaptic vesicle exocytosis [IMP]
- vesicle docking [ISO]
Gene Ontology Molecular Function- SNARE binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [IPI, ISO]
- calmodulin binding [ISO]
- clathrin binding [ISO]
- identical protein binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [ISO]
- phospholipid binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [ISO]
- SNARE binding [ISO]
- calcium ion binding [IDA, ISO]
- calcium-dependent phospholipid binding [ISO, TAS]
- calcium-dependent protein binding [IPI, ISO]
- calmodulin binding [ISO]
- clathrin binding [ISO]
- identical protein binding [ISO]
- low-density lipoprotein particle receptor binding [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [ISO]
- phospholipid binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- syntaxin binding [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
- SNARE complex [ISO]
- cell [IMP]
- cytoplasm [ISO]
- dense core granule [ISO]
- excitatory synapse [ISO]
- intracellular organelle [ISO]
- neuron projection [IDA]
- plasma membrane [ISO, TAS]
- presynaptic membrane [IDA]
- secretory granule [IDA, ISO]
- synaptic vesicle [IDA, ISO, TAS]
- synaptic vesicle membrane [IDA]
- terminal bouton [ISO]
Mus musculus
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
The amyloid precursor protein (APP), whose mutations cause Alzheimer disease, plays an important in vivo role and facilitates transmitter release. Because the APP cytosolic region (ACR) is essential for these functions, we have characterized its brain interactome. We found that the ACR interacts with proteins that regulate the ubiquitin-proteasome system, predominantly with the E3 ubiquitin-protein ligases Stub1, which binds the ... [more]
J. Biol. Chem. Aug. 12, 2016; 291(33);17209-27 [Pubmed: 27325702]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID