BAIT
APP
Abeta, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp
amyloid beta (A4) precursor protein
GO Process (38)
GO Function (10)
GO Component (27)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- axon cargo transport [IGI, IMP]
- axon midline choice point recognition [IMP]
- axonogenesis [IMP]
- cellular copper ion homeostasis [IGI, IMP]
- cholesterol metabolic process [IGI, IMP]
- collateral sprouting in absence of injury [IGI]
- dendrite development [IGI, IMP]
- endocytosis [IMP]
- extracellular matrix organization [IGI]
- forebrain development [IMP]
- ionotropic glutamate receptor signaling pathway [IMP]
- locomotory behavior [IGI]
- mRNA polyadenylation [IDA]
- mating behavior [IGI]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of neuron differentiation [IDA, IGI]
- neuromuscular process controlling balance [IGI]
- neuron apoptotic process [IGI, ISO]
- neuron projection development [IDA]
- neuron remodeling [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of peptidase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein homooligomerization [ISO]
- protein phosphorylation [IMP]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of gene expression [IDA]
- regulation of multicellular organism growth [IMP]
- regulation of protein binding [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of translation [IDA]
- response to oxidative stress [IGI]
- smooth endoplasmic reticulum calcium ion homeostasis [IGI]
- suckling behavior [IGI]
- synaptic growth at neuromuscular junction [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [IDA]
- Golgi apparatus [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA, ISO]
- cell [IGI]
- cell surface [ISO]
- cell-cell junction [IDA]
- ciliary rootlet [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IDA]
- intracellular [IGI]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA, TAS]
- membrane raft [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- smooth endoplasmic reticulum [IGI]
- spindle midzone [IDA]
- terminal bouton [ISO]
Mus musculus
PREY
APOE
AI255918
apolipoprotein E
GO Process (84)
GO Function (19)
GO Component (28)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- N-methyl-D-aspartate receptor clustering [ISO]
- aging [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO]
- artery morphogenesis [IGI]
- axon regeneration [IGI]
- cGMP-mediated signaling [ISO]
- cardiovascular system development [IMP]
- cellular calcium ion homeostasis [IDA]
- cholesterol biosynthetic process [IBA]
- cholesterol catabolic process [IMP]
- cholesterol efflux [IDA, IMP, ISO]
- cholesterol homeostasis [IGI, IMP, ISO]
- cholesterol metabolic process [IMP, ISO]
- chylomicron remnant clearance [ISO]
- fatty acid homeostasis [ISO]
- high-density lipoprotein particle assembly [IBA, ISO]
- high-density lipoprotein particle clearance [ISO]
- high-density lipoprotein particle remodeling [ISO]
- lipid homeostasis [IMP]
- lipid metabolic process [IGI]
- lipid transport [ISO]
- lipoprotein biosynthetic process [IGI]
- lipoprotein catabolic process [IMP]
- lipoprotein metabolic process [IGI, IMP, ISO]
- long-chain fatty acid transport [ISO]
- low-density lipoprotein particle remodeling [IMP]
- maintenance of location in cell [IMP]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of beta-amyloid formation [ISO]
- negative regulation of blood coagulation [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cholesterol biosynthetic process [ISO]
- negative regulation of cholesterol efflux [ISO]
- negative regulation of dendritic spine development [ISO]
- negative regulation of dendritic spine maintenance [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of inflammatory response [IGI]
- negative regulation of lipid biosynthetic process [ISO]
- negative regulation of lipid transport across blood brain barrier [ISO]
- negative regulation of neuron apoptotic process [IBA, ISO]
- negative regulation of neuron death [ISO]
- negative regulation of phospholipid efflux [ISO]
- negative regulation of platelet activation [ISO]
- negative regulation of postsynaptic membrane organization [ISO]
- negative regulation of presynaptic membrane organization [ISO]
- nitric oxide mediated signal transduction [ISO]
- phospholipid efflux [IBA, ISO]
- positive regulation of axon extension [ISO]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of cGMP biosynthetic process [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of cholesterol esterification [IMP, ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of dendritic spine maintenance [ISO]
- positive regulation of lipid biosynthetic process [IBA, ISO]
- positive regulation of lipid transport across blood brain barrier [ISO]
- positive regulation of low-density lipoprotein particle receptor catabolic process [ISO]
- positive regulation of membrane protein ectodomain proteolysis [ISO]
- positive regulation of neurofibrillary tangle assembly [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of nitric-oxide synthase activity [IBA, ISO]
- positive regulation of phospholipid efflux [ISO]
- positive regulation of postsynaptic membrane organization [ISO]
- positive regulation of presynaptic membrane organization [ISO]
- protein import [ISO]
- protein localization [IMP]
- receptor-mediated endocytosis [ISO]
- regulation of Cdc42 protein signal transduction [ISO]
- regulation of axon extension [IBA]
- regulation of beta-amyloid clearance [IBA, ISO]
- regulation of cholesterol transport [IBA]
- regulation of gene expression [IMP]
- regulation of neuron death [ISO]
- regulation of tau-protein kinase activity [ISO]
- response to dietary excess [IMP]
- response to oxidative stress [IMP]
- reverse cholesterol transport [IBA, ISO]
- triglyceride catabolic process [IBA]
- triglyceride metabolic process [ISO]
- vasodilation [IMP]
- very-low-density lipoprotein particle clearance [ISO]
- very-low-density lipoprotein particle remodeling [IMP, ISO]
Gene Ontology Molecular Function- antioxidant activity [ISO]
- beta-amyloid binding [IBA, ISO]
- cholesterol binding [IBA]
- cholesterol transporter activity [IDA]
- heparin binding [ISO]
- hydroxyapatite binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IBA, ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IMP, ISO]
- phospholipid binding [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [IBA, ISO]
- antioxidant activity [ISO]
- beta-amyloid binding [IBA, ISO]
- cholesterol binding [IBA]
- cholesterol transporter activity [IDA]
- heparin binding [ISO]
- hydroxyapatite binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- lipid transporter activity [ISO]
- lipoprotein particle binding [IDA]
- low-density lipoprotein particle receptor binding [IBA, ISO]
- metal chelating activity [ISO]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IMP, ISO]
- phospholipid binding [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- tau protein binding [ISO]
- very-low-density lipoprotein particle receptor binding [IBA, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- blood microparticle [IBA, ISO]
- cell [IDA]
- cell surface [ISO]
- chylomicron [IBA, ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- discoidal high-density lipoprotein particle [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- endosome [ISO]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of external side of plasma membrane [ISO]
- high-density lipoprotein particle [IBA, ISO]
- intermediate-density lipoprotein particle [IBA, ISO]
- late endosome [ISO]
- low-density lipoprotein particle [IDA, ISO]
- lysosome [ISO]
- membrane [ISO]
- microtubule [ISO]
- neuronal cell body [ISO]
- nuclear envelope [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- very-low-density lipoprotein particle [ISO]
- vesicle [ISO]
Mus musculus
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
The amyloid precursor protein (APP), whose mutations cause Alzheimer disease, plays an important in vivo role and facilitates transmitter release. Because the APP cytosolic region (ACR) is essential for these functions, we have characterized its brain interactome. We found that the ACR interacts with proteins that regulate the ubiquitin-proteasome system, predominantly with the E3 ubiquitin-protein ligases Stub1, which binds the ... [more]
J. Biol. Chem. Aug. 12, 2016; 291(33);17209-27 [Pubmed: 27325702]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID