BAIT
HES1
hes family bHLH transcription factor 1
GO Process (75)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- Notch signaling pathway [ISO]
- STAT protein import into nucleus [ISO, ISS]
- adenohypophysis development [ISO]
- aorta morphogenesis [ISO]
- artery morphogenesis [ISO]
- ascending aorta morphogenesis [ISO]
- auditory receptor cell differentiation [ISO]
- auditory receptor cell fate determination [ISO]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISO]
- cell adhesion [ISO]
- cell fate commitment [ISO]
- cell maturation [ISO]
- cell migration [ISO]
- cell morphogenesis involved in neuron differentiation [ISO]
- cochlea development [ISO]
- common bile duct development [ISO]
- embryonic heart tube morphogenesis [ISO]
- forebrain radial glial cell differentiation [IDA]
- hindbrain morphogenesis [ISO]
- in utero embryonic development [ISO]
- labyrinthine layer blood vessel development [ISO]
- lateral inhibition [ISO]
- liver development [ISO]
- lung development [ISO]
- midbrain development [ISO]
- midbrain-hindbrain boundary morphogenesis [ISO]
- negative regulation of auditory receptor cell differentiation [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of forebrain neuron differentiation [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of glial cell proliferation [ISO, ISS]
- negative regulation of inner ear receptor cell differentiation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of oligodendrocyte differentiation [ISO, ISS]
- negative regulation of pancreatic A cell differentiation [ISO]
- negative regulation of pro-B cell differentiation [ISO, ISS]
- negative regulation of stem cell differentiation [ISO]
- negative regulation of stomach neuroendocrine cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neural tube development [ISO]
- neuronal stem cell maintenance [IDA, ISO]
- oculomotor nerve development [ISO]
- outflow tract morphogenesis [ISO]
- pancreas development [ISO]
- pattern specification process [ISO]
- pharyngeal arch artery morphogenesis [ISO]
- pituitary gland development [ISO]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of DNA binding [ISO, ISS]
- positive regulation of JAK-STAT cascade [ISO, ISS]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of astrocyte differentiation [ISO, ISS]
- positive regulation of cell proliferation [ISO]
- positive regulation of mitotic cell cycle, embryonic [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO, ISS]
- protein complex assembly [ISO, ISS]
- regulation of fat cell differentiation [ISO]
- regulation of neurogenesis [ISO]
- regulation of secondary heart field cardioblast proliferation [ISO]
- regulation of timing of cell differentiation [ISO]
- regulation of timing of neuron differentiation [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- smoothened signaling pathway [ISO]
- somatic stem cell maintenance [ISO]
- telencephalon development [ISO]
- thymus development [ISO]
- transcription from RNA polymerase II promoter [ISO]
- trochlear nerve development [ISO]
- vascular smooth muscle cell development [ISO]
- ventricular septum development [ISO]
- ventricular septum morphogenesis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- E-box binding [IDA]
- N-box binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO, ISS]
- chaperone binding [ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI]
- DNA binding [ISO]
- E-box binding [IDA]
- N-box binding [ISO, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO, ISS]
- chaperone binding [ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- cytoplasm [ISO]
- intracellular [ISO]
- nucleoplasm [ISO, TAS]
- nucleus [ISO, ISS]
Rattus norvegicus
PREY
TLE3
ESG, ESG3, GRG3, HsT18976
transducin-like enhancer of split 3
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [TAS]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3Â Ubiquitin Ligase Hyd/UBR5.
Extracellular signals are transduced to the cell nucleus by effectors that bind to enhancer complexes to operate transcriptional switches. For example, the Wnt enhanceosome is a multiprotein complex associated with Wnt-responsive enhancers through T cell factors (TCF) and kept silent by Groucho/TLE co-repressors. Wnt-activated β-catenin binds to TCF to overcome this repression, but how it achieves this is unknown. Here, we ... [more]
Mol. Cell Jul. 20, 2017; 67(2);181-193.e5 [Pubmed: 28689657]
Throughput
- Low Throughput
Curated By
- BioGRID