BAIT

HIST1H2AA

H2AA, H2AFR, bA317E16.2
histone cluster 1, H2aa
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens
PREY

TLE3

ESG, ESG3, GRG3, HsT18976
transducin-like enhancer of split 3
Autism spectrum disorder (ASD) Project
UPS Project
GO Process (3)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.

Flack JE, Mieszczanek J, Novcic N, Bienz M

Extracellular signals are transduced to the cell nucleus by effectors that bind to enhancer complexes to operate transcriptional switches. For example, the Wnt enhanceosome is a multiprotein complex associated with Wnt-responsive enhancers through T cell factors (TCF) and kept silent by Groucho/TLE co-repressors. Wnt-activated β-catenin binds to TCF to overcome this repression, but how it achieves this is unknown. Here, we ... [more]

Mol. Cell Jul. 20, 2017; 67(2);181-193.e5 [Pubmed: 28689657]

Throughput

  • Low Throughput

Curated By

  • BioGRID