FRS2
Gene Ontology Biological Process
- activation of MAPK activity [IMP]
- anterior/posterior axis specification, embryo [IMP]
- fibroblast growth factor receptor signaling pathway [IGI, IMP, ISO]
- forebrain development [IMP]
- gastrulation with mouth forming second [IMP]
- lens development in camera-type eye [IMP]
- lens fiber cell development [IGI, IMP]
- neuroblast proliferation [IGI, IMP]
- optic placode formation involved in camera-type eye formation [IMP]
- organ induction [IMP]
- positive regulation of signal transduction [IDA]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IMP]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of apoptotic process [IMP]
- regulation of epithelial cell proliferation [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
- ventricular septum development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FGFR1
Gene Ontology Biological Process
- angiogenesis [IGI]
- auditory receptor cell development [IMP]
- blood vessel morphogenesis [IMP]
- brain development [IMP]
- branching involved in salivary gland morphogenesis [IMP]
- cell maturation [IMP]
- chondrocyte differentiation [IGI]
- embryonic limb morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, ISO]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [IMP]
- generation of neurons [IMP]
- in utero embryonic development [IGI]
- inner ear morphogenesis [IMP]
- lung development [IGI, IMP]
- lung-associated mesenchyme development [IGI]
- mesenchymal cell differentiation [IGI]
- midbrain development [IGI, IMP]
- middle ear morphogenesis [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- orbitofrontal cortex development [IMP]
- organ induction [IMP]
- outer ear morphogenesis [IMP]
- paraxial mesoderm development [IGI]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [IGI]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle [IMP]
- positive regulation of cell proliferation [IDA, IGI, IMP, ISO]
- positive regulation of mesenchymal cell proliferation [IGI, IMP]
- positive regulation of neuron projection development [IGI]
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [IDA]
- regulation of cell proliferation [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- regulation of gene expression [IMP]
- regulation of lateral mesodermal cell fate specification [IGI]
- salivary gland morphogenesis [IMP]
- sensory perception of sound [IMP]
- ureteric bud development [IGI]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventricular zone neuroblast division [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.
Binding of the fibroblast growth factor (FGF) to the FGF receptor (FGFR) tyrosine kinase leads to receptor tyrosine autophosphorylation as well as phosphorylation of multiple downstream signaling molecules that are recruited to the receptor either by direct binding or through adaptor proteins. The FGFR substrate 2 (FRS2) family consists of two members, FRS2alpha and FRS2beta, and has been shown to ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FGFR1 FRS2 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 636475 |
Curated By
- BioGRID