FGFR1
Gene Ontology Biological Process
- angiogenesis [IGI]
- auditory receptor cell development [IMP]
- blood vessel morphogenesis [IMP]
- brain development [IMP]
- branching involved in salivary gland morphogenesis [IMP]
- cell maturation [IMP]
- chondrocyte differentiation [IGI]
- embryonic limb morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, ISO]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [IMP]
- generation of neurons [IMP]
- in utero embryonic development [IGI]
- inner ear morphogenesis [IMP]
- lung development [IGI, IMP]
- lung-associated mesenchyme development [IGI]
- mesenchymal cell differentiation [IGI]
- midbrain development [IGI, IMP]
- middle ear morphogenesis [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- orbitofrontal cortex development [IMP]
- organ induction [IMP]
- outer ear morphogenesis [IMP]
- paraxial mesoderm development [IGI]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway [IGI]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle [IMP]
- positive regulation of cell proliferation [IDA, IGI, IMP, ISO]
- positive regulation of mesenchymal cell proliferation [IGI, IMP]
- positive regulation of neuron projection development [IGI]
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling [IDA]
- regulation of cell proliferation [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- regulation of gene expression [IMP]
- regulation of lateral mesodermal cell fate specification [IGI]
- salivary gland morphogenesis [IMP]
- sensory perception of sound [IMP]
- ureteric bud development [IGI]
- vasculogenesis involved in coronary vascular morphogenesis [TAS]
- ventricular zone neuroblast division [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRB2
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Ras protein signal transduction [TAS]
- T cell costimulation [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell-cell signaling [TAS]
- cellular response to ionizing radiation [IMP]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [IPI, TAS]
- leukocyte migration [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- receptor internalization [IMP]
- signal transduction in response to DNA damage [IMP]
Gene Ontology Molecular Function- SH3 domain binding [IDA]
- SH3/SH2 adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [IPI]
- identical protein binding [IPI]
- insulin receptor substrate binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- SH3 domain binding [IDA]
- SH3/SH2 adaptor activity [TAS]
- ephrin receptor binding [IPI]
- epidermal growth factor receptor binding [IPI]
- identical protein binding [IPI]
- insulin receptor substrate binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (Fgfr1) is mediated by alternative splicing of the juxtamembrane domain.
Fibroblast growth factor receptors (FGFRs) are a family of transmembrane tyrosine kinases involved in signaling via interactions with the family of fibroblast growth factors. Alternative splicing of the juxtamembrane region of FGFR1-3 leads to the inclusion or exclusion of two amino acids, valine and threonine, the VT site. The presence or absence of VT (VT+ or VT-, respectively) affects the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID