BAIT
HIF3A
Ipas, MOP7, NEPAS, bHLHe17
hypoxia inducible factor 3, alpha subunit
GO Process (6)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of nucleic acid-templated transcription [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IPI]
- response to hypoxia [IDA]
- transcription from RNA polymerase II promoter [IPI]
Gene Ontology Molecular Function
Mus musculus
PREY
ARNT
HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2
aryl hydrocarbon receptor nuclear translocator
GO Process (13)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- mRNA transcription from RNA polymerase II promoter [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- response to hypoxia [IDA]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.
Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that regulate a number of adaptive responses to low oxygen tension. They are composed of alpha- and beta-subunits that belong to the basic helix-loop-helix-PAS (bHLH-PAS) superfamily. In our efforts to identify new bHLH-PAS proteins, we cloned a cDNA encoding a novel alpha-class hypoxia inducible factor, HIF3alpha. The HIF3alpha open reading frame encodes ... [more]
Gene Expr. Dec. 05, 1998; 7(3);205-13 [Pubmed: 9840812]
Throughput
- Low Throughput
Additional Notes
- gel shift
Curated By
- BioGRID