ARNT
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- mRNA transcription from RNA polymerase II promoter [IC]
- positive regulation of endothelial cell proliferation [IC]
- positive regulation of erythrocyte differentiation [IC]
- positive regulation of glycolytic process [IC]
- positive regulation of hormone biosynthetic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IC]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- response to hypoxia [IDA]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor binding [IPI]
- enhancer binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
AHR
Gene Ontology Biological Process
- B cell differentiation [TAS]
- B cell homeostasis [IMP, TAS]
- B-1 B cell homeostasis [TAS]
- T cell homeostasis [IMP]
- blood circulation [IMP]
- blood vessel development [IMP]
- blood vessel morphogenesis [IMP]
- blood vessel remodeling [IMP]
- camera-type eye development [IMP]
- cardiac left ventricle morphogenesis [IMP]
- cell morphogenesis [IMP]
- cellular response to cAMP [IDA]
- circadian regulation of gene expression [IDA]
- circumferential growth involved in left ventricle morphogenesis [IMP]
- common bile duct development [IMP]
- embryonic hemopoiesis [IMP]
- gland development [IMP]
- glomerulus morphogenesis [IMP]
- immune system process [IMP]
- intracellular receptor signaling pathway [IDA, ISO]
- kidney morphogenesis [IMP]
- liver development [IMP]
- lymphocyte homeostasis [IMP, TAS]
- negative regulation of necrotic cell death [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of vasoconstriction [IMP]
- ovarian follicle development [ISO]
- patterning of blood vessels [IMP]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- positive regulation of cell size [IMP]
- positive regulation of growth [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic hemopoiesis [IMP]
- prostate gland development [IMP]
- regulation of B cell proliferation [ISO]
- regulation of blood pressure [TAS]
- regulation of blood vessel size [IMP]
- regulation of gene expression [ISO]
- regulation of heart growth [TAS]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA, ISO, TAS]
- reproductive structure development [IMP]
- response to organic cyclic compound [ISO]
- response to stress [IDA]
- response to toxic substance [IDA, ISO]
- response to xenobiotic stimulus [IDA, ISO]
- smooth muscle tissue development [IMP]
- spleen development [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- venous blood vessel development [IMP]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [IDA]
- Hsp90 protein binding [ISO, TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor activity [ISO]
- enhancer binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- E-box binding [IDA]
- Hsp90 protein binding [ISO, TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor activity [ISO]
- enhancer binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Novel DNA binding by a basic helix-loop-helix protein. The role of the dioxin receptor PAS domain.
Central issues surrounding the basic helix-loop-helix (bHLH) superfamily of dimeric transcription factors concern how specificity of partner selection and DNA binding are achieved. bHLH proteins bind DNA through the basic sequence that is contiguous with a helix-loop-helix dimerization domain. For the two subgroups within the family, dimerization is further regulated by an adjacent Per-Arnt-Sim homology (PAS) or leucine zipper (LZ) ... [more]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID