BAIT
MTF1
MTF-1, Thyls, RP23-168M5.2
metal response element binding transcription factor 1
GO Process (5)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- core promoter binding [ISO]
- histone acetyltransferase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- core promoter binding [ISO]
- histone acetyltransferase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
- nucleoplasm [ISO]
- nucleus [IC]
Mus musculus
PREY
HIF1A
AA959795, HIF1alpha, MOP1, bHLHe78
hypoxia inducible factor 1, alpha subunit
GO Process (75)
GO Function (18)
GO Component (8)
Gene Ontology Biological Process
- B-1 B cell homeostasis [IMP]
- angiogenesis [IMP]
- axon transport of mitochondrion [ISO]
- blood vessel development [IMP]
- blood vessel morphogenesis [IMP]
- cardiac ventricle morphogenesis [IMP]
- cartilage development [IMP]
- cell differentiation [IGI, IMP]
- cellular iron ion homeostasis [IMP]
- cellular response to hypoxia [IGI, ISO]
- cerebral cortex development [IMP]
- collagen metabolic process [IMP]
- connective tissue replacement involved in inflammatory response wound healing [IMP]
- digestive tract morphogenesis [IMP]
- dopaminergic neuron differentiation [IGI, IMP]
- elastin metabolic process [IMP]
- embryonic hemopoiesis [IMP]
- embryonic placenta development [IGI, IMP]
- epithelial cell differentiation involved in mammary gland alveolus development [IMP]
- epithelial to mesenchymal transition [IMP]
- glucose homeostasis [IMP]
- heart looping [IMP]
- hemoglobin biosynthetic process [IMP]
- hypoxia-inducible factor-1alpha signaling pathway [IDA]
- intestinal epithelial cell maturation [IMP]
- lactate metabolic process [IMP]
- lactation [IMP]
- muscle cell cellular homeostasis [IMP]
- negative regulation of TOR signaling [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [IMP]
- negative regulation of growth [IMP]
- negative regulation of mesenchymal cell apoptotic process [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- negative regulation of thymocyte apoptotic process [IMP]
- negative regulation of transcription elongation from RNA polymerase II promoter [ISO]
- negative regulation of vasoconstriction [ISO]
- neural crest cell migration [IMP]
- neural fold elevation formation [IMP]
- outflow tract morphogenesis [IMP]
- oxygen homeostasis [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of neuroblast proliferation [IGI]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of catalytic activity [IMP]
- regulation of cell proliferation [IMP]
- regulation of gene expression [ISO]
- regulation of glycolytic process [IGI]
- regulation of thymocyte apoptotic process [IGI]
- regulation of transcription from RNA polymerase II promoter [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP, ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transforming growth factor beta2 production [ISO]
- response to fungicide [ISO]
- response to hypoxia [IDA, IGI, IMP, ISO]
- response to muscle activity [IMP]
- retina vasculature development in camera-type eye [IMP]
- signal transduction [ISO]
- transcription from RNA polymerase II promoter [IPI]
- vascular endothelial growth factor production [ISO]
- vasculature development [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, IGI]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA, IGI]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha.
Mammalian metallothionein (MT) genes are transcriptionally activated by the essential metal zinc as well as by environmental stresses, including toxic metal overload and redox fluctuations. In addition to playing a key role in zinc homeostasis, MT proteins can protect against metal- and oxidant-induced cellular damage, and may participate in other fundamental physiologic and pathologic processes such as cell survival, proliferation, ... [more]
Mol. Cancer Res. Mar. 01, 2008; 6(3);483-90 [Pubmed: 18337454]
Throughput
- Low Throughput
Curated By
- BioGRID