BAIT
NDN
AI528698, Peg6
necdin
GO Process (17)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- axon extension [IMP]
- axonal fasciculation [IMP]
- axonogenesis [IMP]
- cellular calcium ion homeostasis [TAS]
- central nervous system development [IMP]
- genetic imprinting [IMP]
- glial cell migration [IMP]
- multicellular organismal homeostasis [IMP]
- neuron development [IMP]
- neuron migration [IMP]
- neurotrophin TRK receptor signaling pathway [IMP]
- post-embryonic development [IMP]
- regulation of cell growth [TAS]
- regulation of transcription, DNA-templated [IGI]
- respiratory gaseous exchange [IMP]
- respiratory system process [IMP]
- sensory perception of pain [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
ARNT
D3Ertd557e, Drnt, ESTM42, Hif1b, W08714, bHLHe2, mKIAA4051
aryl hydrocarbon receptor nuclear translocator
GO Process (13)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell differentiation [IMP]
- embryonic placenta development [IMP]
- intracellular receptor signaling pathway [IMP]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of nucleic acid-templated transcription [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [TAS]
- response to hypoxia [IDA, ISO]
- response to toxic substance [TAS]
Gene Ontology Molecular Function- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.
PWS is caused by the loss of expression of a set of maternally imprinted genes including NECDIN (NDN). NDN is expressed in post-mitotic neurons and plays an essential role in PWS as mouse models lacking only the Ndn gene mimic aspects of this disease. Patients haploid for SIM1 develop a PW-like syndrome. Here, we report that NDN directly interacts with ... [more]
Biochem. Biophys. Res. Commun. Nov. 09, 2007; 363(1);113-8 [Pubmed: 17826745]
Throughput
- Low Throughput
Curated By
- BioGRID