ARNT2
Gene Ontology Biological Process
- brain development [ISO]
- central nervous system development [IMP]
- negative regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [ISA]
- response to hypoxia [ISO, TAS]
- response to toxic substance [TAS]
- response to xenobiotic stimulus [TAS]
- signal transduction [NAS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- aryl hydrocarbon receptor binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- aryl hydrocarbon receptor binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
NDN
Gene Ontology Biological Process
- axon extension [IMP]
- axonal fasciculation [IMP]
- axonogenesis [IMP]
- cellular calcium ion homeostasis [TAS]
- central nervous system development [IMP]
- genetic imprinting [IMP]
- glial cell migration [IMP]
- multicellular organismal homeostasis [IMP]
- neuron development [IMP]
- neuron migration [IMP]
- neurotrophin TRK receptor signaling pathway [IMP]
- post-embryonic development [IMP]
- regulation of cell growth [TAS]
- regulation of transcription, DNA-templated [IGI]
- respiratory gaseous exchange [IMP]
- respiratory system process [IMP]
- sensory perception of pain [IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.
PWS is caused by the loss of expression of a set of maternally imprinted genes including NECDIN (NDN). NDN is expressed in post-mitotic neurons and plays an essential role in PWS as mouse models lacking only the Ndn gene mimic aspects of this disease. Patients haploid for SIM1 develop a PW-like syndrome. Here, we report that NDN directly interacts with ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NDN ARNT2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NDN ARNT2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID