BAIT

VAC17

YCL062W, YCL063W
Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

PIB2

S000007475, YGL023C
Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Lethality

A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.

Publication

Pib2 and EGO Complex are both required for activation of TORC1.

Varlakhanova NV, Mihalevic M, Bernstein KA, Ford MGJ

The TORC1 complex is a key regulator of cell growth and metabolism in Saccharomyces cerevisiae The vacuole-associated EGO Complex couples activation of TORC1 to the availability of amino acids, specifically glutamine and leucine. EGO Complex is also essential for reactivation of TORC1 following rapamycin-induced growth arrest and for its distribution on the vacuolar membrane. Pib2, a FYVE-containing PI3P-binding protein, is ... [more]

J. Cell. Sci. Oct. 09, 2017; (); [Pubmed: 28993463]

Throughput

  • High Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • pib2 was lethal when overexpressed in the mutant background

Curated By

  • BioGRID