BAIT
NR3C2
MCR, MLR, MR, NR3C2VIT
nuclear receptor subfamily 3, group C, member 2
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CASP8AP2
CED-4, FLASH, RIP25, RP11-63K6.3
caspase 8 associated protein 2
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- Fas signaling pathway [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP, ISS]
- apoptotic signaling pathway [TAS]
- cellular response to mechanical stimulus [IEP]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP, ISS]
- negative regulation of nucleic acid-templated transcription [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
DAXX, FLASH, and FAF-1 modulate mineralocorticoid and glucocorticoid receptor-mediated transcription in hippocampal cells--toward a basis for the opposite actions elicited by two nuclear receptors?
Mineralocorticoid (MR) and glucocorticoid (GR) receptors are two closely-related members of the steroid nuclear receptor family of transcription factors that bind common ligands in the brain (corticosterone and cortisol) and supposedly have identical hormone response elements. This raises the important question of how they can elicit differential biological actions in neurons in which they are often colocalized. One plausible explanation ... [more]
Mol. Pharmacol. Mar. 01, 2004; 65(3);761-9 [Pubmed: 14978255]
Throughput
- Low Throughput
Curated By
- BioGRID