NRIP1
Gene Ontology Biological Process
- circadian regulation of gene expression [IMP, ISO]
- lipid storage [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- ovarian follicle rupture [IMP]
- ovulation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- core promoter sequence-specific DNA binding [ISO]
- estrogen receptor binding [ISO]
- glucocorticoid receptor binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- receptor binding [IPI]
- retinoic acid receptor binding [IPI]
- retinoid X receptor binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [IDA, ISO]
- core promoter sequence-specific DNA binding [ISO]
- estrogen receptor binding [ISO]
- glucocorticoid receptor binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- receptor binding [IPI]
- retinoic acid receptor binding [IPI]
- retinoid X receptor binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [IDA, ISO]
Gene Ontology Cellular Component
CTBP1
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- negative regulation of cell proliferation [TAS]
- negative regulation of histone H4 acetylation [IMP]
- negative regulation of histone acetylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of histone deacetylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell cycle [IMP]
- viral genome replication [TAS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP.
CtBP (carboxyl-terminal binding protein) participates in regulating cellular development and differentiation by associating with a diverse array of transcriptional repressors. Most of these interactions occur through a consensus CtBP-binding motif, PXDLS, in the repressor proteins. We previously showed that the CtBP-binding motif in E1A is flanked by a Lys residue and suggested that acetylation of this residue by the p300/CBP-associated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NRIP1 CTBP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| CTBP1 NRIP1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID