BAIT

ARR1

ACR1, YAP8, L000004292, YPR199C
Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds
Saccharomyces cerevisiae (S288c)
PREY

ISA2

L000004955, YPR067W
Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Transcriptional regulation of FeS biogenesis genes: A possible shield against arsenate toxicity activated by Yap1.

da Silva SM, Batista-Nascimento L, Gaspar-Cordeiro A, Vernis L, Pimentel C, Rodrigues-Pousada C

In the eukaryotic model yeast Saccharomyces cerevisiae, arsenic (As) detoxification is regulated by two transcriptional factors, Yap8 and Yap1. Yap8 specifically controls As extrusion from the cell, whether Yap1 avoids arsenic-induced oxidative damages. Accordingly, cells lacking both Yap1 and Yap8 are more sensitive to arsenate than cells lacking each regulator individually. Strikingly enough, the same sensitivity pattern was observed under ... [more]

Biochim. Biophys. Acta Jul. 17, 2018; 1862(10);2152-2161 [Pubmed: 30025855]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: resistance to chemicals (APO:0000087)
  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • Overexpression of NAR1, ISA2 or YFH1 clearly alleviated the yap/1yap8 mutant growth defect
  • genetic complex

Curated By

  • BioGRID