SPARC
Gene Ontology Biological Process
- bone development [ISO]
- cellular response to growth factor stimulus [ISO]
- heart development [IEP]
- inner ear development [IEP]
- lung development [IMP]
- negative regulation of angiogenesis [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- ossification [IEP]
- positive regulation of endothelial cell migration [ISO]
- regulation of cell morphogenesis [ISO]
- regulation of cell proliferation [ISO]
- response to L-ascorbic acid [IEP]
- response to cAMP [IEP]
- response to cadmium ion [IEP]
- response to calcium ion [IEP]
- response to cytokine [IEP]
- response to ethanol [IEP]
- response to glucocorticoid [IEP]
- response to gravity [IEP]
- response to lead ion [IEP]
- response to lipopolysaccharide [IEP]
- response to peptide hormone [IEP]
- wound healing [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FGF2
Gene Ontology Biological Process
- activation of MAPKK activity [ISO]
- aging [IEP]
- angiogenesis [ISO]
- angiogenesis involved in coronary vascular morphogenesis [IMP]
- branching involved in ureteric bud morphogenesis [ISO, ISS]
- cell migration involved in sprouting angiogenesis [ISO]
- chondroblast differentiation [ISO]
- corticotropin hormone secreting cell differentiation [ISO]
- embryo development ending in birth or egg hatching [IMP]
- fibroblast growth factor receptor signaling pathway [IPI, ISO]
- glial cell differentiation [ISO]
- hyaluronan catabolic process [ISO]
- inositol phosphate biosynthetic process [ISO]
- lung development [ISO]
- mammary gland epithelial cell differentiation [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cell death [ISO, ISS]
- negative regulation of cell proliferation [ISO]
- negative regulation of fibroblast migration [ISO]
- negative regulation of wound healing [ISO]
- organ induction [ISO]
- phosphatidylinositol biosynthetic process [ISO]
- positive chemotaxis [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cardiac muscle cell proliferation [IDA, ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell fate specification [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of cerebellar granule cell precursor proliferation [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell cycle [ISO]
- regulation of retinal cell programmed cell death [ISO]
- release of sequestered calcium ion into cytosol [ISO]
- response to axon injury [ISO]
- stem cell development [ISO]
- substantia nigra development [ISO]
- thyroid-stimulating hormone-secreting cell differentiation [ISO]
- wound healing [IEP]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Fibroblast growth factor receptor-1 mediates the inhibition of endothelial cell proliferation and the promotion of skeletal myoblast differentiation by SPARC: a role for protein kinase A.
The role of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) in modulation of vascular cell proliferation is believed to be mediated, in part, by its ability to regulate the activity of certain growth factors through direct binding. In this study, we demonstrate that SPARC does not bind to basic fibroblast growth factor (bFGF/FGF-2) or interfere with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID