A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.

Isogai E, Ohira M, Ozaki T, Oba S, Nakamura Y, Nakagawara A

Expression of Mash1 is dysregulated in human neuroblastoma. We have also reported that LMO3 (LIM-only protein 3) has an oncogenic potential in collaboration with neuronal transcription factor HEN2 in neuroblastoma. However, the precise molecular mechanisms of its transcriptional regulation remain elusive. Here we found that LMO3 forms a complex with HEN2 and acts as an upstream mediator for transcription of ... [more]

PLoS ONE May. 05, 2011; 6(5);e19297 [Pubmed: 21573214]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

NHLH2

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II activating transcription factor binding [IPI]protein binding [IPI]

Gene Ontology Cellular Component

LMO3