BAIT
ASNA1
ARSA-I, ARSA1, ASNA-I, GET3, TRC40, hASNA-I
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
GO Process (2)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
POLR3B
C128, HLD8, INMAP, RPC2
polymerase (RNA) III (DNA directed) polypeptide B
GO Process (8)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- gene expression [TAS]
- innate immune response [TAS]
- positive regulation of innate immune response [IMP]
- positive regulation of interferon-beta production [IMP]
- positive regulation of type I interferon production [TAS]
- termination of RNA polymerase III transcription [TAS]
- transcription elongation from RNA polymerase III promoter [TAS]
- transcription from RNA polymerase III promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Mapping the Genetic Landscape of Human Cells.
Seminal yeast studies have established the value of comprehensively mapping genetic interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets underscore the utility of this approach, but the feasibility of generating large-scale, diverse human GI maps remains unresolved. We developed a CRISPR interference platform for large-scale quantitative mapping of human GIs. We systematically perturbed 222,784 ... [more]
Cell Jul. 17, 2018; (); [Pubmed: 30033366]
Quantitative Score
- -4.277506133 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- cell type: k-562 cell (BTO:0000664)
- phenotype: growth abnormality (HP:0001507)
Additional Notes
- CRISPR GI screen
- Cell Line: K562 EFO:0002067/Jurkat EFO:0002796
- Experimental Setup: Timecourse
- GIST: A-phenotypic negative/positive genetic interaction
- Interactions in this CRISPR interference (CRISPRi) analysis were considered to be significant when GI <= -3 (negative genetic interaction) or GI >= 3 (positive genetic interaction).
- K562 cell line Replicate Average GI score = -4.277506133
- Library: CRISPRi v1
- Significance Threshold: (positive genetic interaction) 3
Curated By
- BioGRID