BAIT
DUT
dUTPase
deoxyuridine triphosphatase
GO Process (8)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- DNA replication [TAS]
- dUMP biosynthetic process [IBA]
- dUTP catabolic process [IBA]
- nucleobase-containing compound metabolic process [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- pyrimidine nucleobase metabolic process [TAS]
- pyrimidine nucleoside biosynthetic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NAMPT
1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
nicotinamide phosphoribosyltransferase
GO Process (13)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- NAD metabolic process [TAS]
- adipose tissue development [IDA]
- cell-cell signaling [TAS]
- circadian regulation of gene expression [ISS]
- insulin receptor signaling pathway [IDA]
- nicotinamide metabolic process [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of nitric-oxide synthase biosynthetic process [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Mapping the Genetic Landscape of Human Cells.
Seminal yeast studies have established the value of comprehensively mapping genetic interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets underscore the utility of this approach, but the feasibility of generating large-scale, diverse human GI maps remains unresolved. We developed a CRISPR interference platform for large-scale quantitative mapping of human GIs. We systematically perturbed 222,784 ... [more]
Cell Jul. 17, 2018; (); [Pubmed: 30033366]
Quantitative Score
- -5.285213613 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
- cell type: jurkat cell (BTO:0000661)
Additional Notes
- CRISPR GI screen
- Cell Line: K562 EFO:0002067/Jurkat EFO:0002796
- Experimental Setup: Timecourse
- GIST: A-phenotypic negative/positive genetic interaction
- Interactions in this CRISPR interference (CRISPRi) analysis were considered to be significant when GI <= -3 (negative genetic interaction) or GI >= 3 (positive genetic interaction).
- Jurkat cell line Replicate Average GI score = -5.285213613
- Library: CRISPRi v1
- Significance Threshold: (positive genetic interaction) 3
Curated By
- BioGRID