BAIT
KDM1A
AOF2, BHC110, KDM1, LSD1, RP1-184J9.1
lysine (K)-specific demethylase 1A
GO Process (15)
GO Function (16)
GO Component (4)
Gene Ontology Biological Process
- blood coagulation [TAS]
- histone H3-K4 demethylation [IDA]
- histone H3-K9 demethylation [IDA]
- muscle cell development [ISS]
- negative regulation of DNA binding [IC]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- negative regulation of protein binding [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein demethylation [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- MRF binding [IDA]
- androgen receptor binding [IDA]
- chromatin binding [IDA]
- demethylase activity [IMP]
- enzyme binding [IPI]
- flavin adenine dinucleotide binding [IDA]
- histone demethylase activity [IDA]
- histone demethylase activity (H3-K4 specific) [IDA]
- histone demethylase activity (H3-K9 specific) [IDA]
- histone demethylase activity (H3-dimethyl-K4 specific) [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- oxidoreductase activity [IDA]
- p53 binding [IPI]
- protein binding [IPI]
- transcription factor binding [IDA]
- transcription regulatory region DNA binding [ISS]
- MRF binding [IDA]
- androgen receptor binding [IDA]
- chromatin binding [IDA]
- demethylase activity [IMP]
- enzyme binding [IPI]
- flavin adenine dinucleotide binding [IDA]
- histone demethylase activity [IDA]
- histone demethylase activity (H3-K4 specific) [IDA]
- histone demethylase activity (H3-K9 specific) [IDA]
- histone demethylase activity (H3-dimethyl-K4 specific) [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [IMP]
- oxidoreductase activity [IDA]
- p53 binding [IPI]
- protein binding [IPI]
- transcription factor binding [IDA]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
NDUFA9
CC6, CI-39k, CI39k, NDUFS2L, SDR22E1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
GO Process (5)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Mapping the Genetic Landscape of Human Cells.
Seminal yeast studies have established the value of comprehensively mapping genetic interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets underscore the utility of this approach, but the feasibility of generating large-scale, diverse human GI maps remains unresolved. We developed a CRISPR interference platform for large-scale quantitative mapping of human GIs. We systematically perturbed 222,784 ... [more]
Cell Jul. 17, 2018; (); [Pubmed: 30033366]
Quantitative Score
- -3.101989886 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
- cell type: jurkat cell (BTO:0000661)
Additional Notes
- CRISPR GI screen
- Cell Line: K562 EFO:0002067/Jurkat EFO:0002796
- Experimental Setup: Timecourse
- GIST: A-phenotypic negative/positive genetic interaction
- Interactions in this CRISPR interference (CRISPRi) analysis were considered to be significant when GI <= -3 (negative genetic interaction) or GI >= 3 (positive genetic interaction).
- Jurkat cell line Replicate Average GI score = -3.101989886
- Library: CRISPRi v1
- Significance Threshold: (positive genetic interaction) 3
Curated By
- BioGRID