CTBP1
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- negative regulation of cell proliferation [TAS]
- negative regulation of histone H4 acetylation [IMP]
- negative regulation of histone acetylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of histone deacetylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell cycle [IMP]
- viral genome replication [TAS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KAT2B
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [IDA]
- Notch signaling pathway [TAS]
- cell cycle arrest [TAS]
- cellular response to insulin stimulus [IDA]
- chromatin organization [TAS]
- chromatin remodeling [IDA, NAS]
- gene expression [TAS]
- histone H3 acetylation [IDA]
- internal peptidyl-lysine acetylation [IDA]
- negative regulation of cell proliferation [IDA]
- peptidyl-lysine acetylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein acetylation [TAS]
- regulation of protein ADP-ribosylation [IDA]
- transcription from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- acetyltransferase activity [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [ISS]
- histone acetyltransferase activity [IDA]
- histone deacetylase binding [IPI]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISS]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISS]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IPI]
- transcription factor binding [IPI]
- acetyltransferase activity [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [ISS]
- histone acetyltransferase activity [IDA]
- histone deacetylase binding [IPI]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISS]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISS]
- transcription coactivator activity [IDA]
- transcription cofactor activity [IPI]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Biochemical Activity
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
BRCA2 associates with acetyltransferase activity when bound to P/CAF.
Predisposition to hereditary breast cancer has been attributed in part to inherited mutations in the BRCA2 gene. The large protein it encodes is still poorly characterized with respect to functions. We have previously shown that BRCA2 has transcriptional activation potential conferred by its amino-terminal third exon. Here, we show that BRCA2 interacts with a transcriptional co-activator protein, P/CAF, which possesses ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CTBP1 KAT2B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CTBP1 KAT2B | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID