BAIT
LONP1
LON, LONP, LonHS, PIM1, PRSS15, hLON
lon peptidase 1, mitochondrial
GO Process (8)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- cellular response to oxidative stress [IC, IDA]
- mitochondrial DNA metabolic process [NAS]
- mitochondrial genome maintenance [NAS]
- mitochondrion organization [IMP]
- oxidation-dependent protein catabolic process [IMP]
- protein homooligomerization [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- response to hypoxia [IEP]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATP-dependent peptidase activity [IDA]
- DNA polymerase binding [IPI]
- G-quadruplex DNA binding [IDA]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA]
- mitochondrial light strand promoter sense binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- single-stranded RNA binding [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATP-dependent peptidase activity [IDA]
- DNA polymerase binding [IPI]
- G-quadruplex DNA binding [IDA]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA]
- mitochondrial light strand promoter sense binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- single-stranded RNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
PITRM1
MP1, PreP, RP11-298E9.1
pitrilysin metallopeptidase 1
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Mapping the Genetic Landscape of Human Cells.
Seminal yeast studies have established the value of comprehensively mapping genetic interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets underscore the utility of this approach, but the feasibility of generating large-scale, diverse human GI maps remains unresolved. We developed a CRISPR interference platform for large-scale quantitative mapping of human GIs. We systematically perturbed 222,784 ... [more]
Cell Jul. 17, 2018; (); [Pubmed: 30033366]
Quantitative Score
- -5.262433641 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
- cell type: jurkat cell (BTO:0000661)
- cell type: k-562 cell (BTO:0000664)
Additional Notes
- CRISPR GI screen
- Cell Line: K562 EFO:0002067/Jurkat EFO:0002796
- Experimental Setup: Timecourse
- GIST: A-phenotypic negative/positive genetic interaction
- Interactions in this CRISPR interference (CRISPRi) analysis were considered to be significant when GI <= -3 (negative genetic interaction) or GI >= 3 (positive genetic interaction).
- Jurkat cell line Replicate Average GI score = -3.759840965
- K562 cell line Replicate Average GI score = -5.262433641
- Library: CRISPRi v1
- Significance Threshold: (positive genetic interaction) 3
Curated By
- BioGRID