BAIT
MBTPS2
BRESEK, IFAP, KFSD, KFSDX, OLMSX, S2P
membrane-bound transcription factor peptidase, site 2
GO Process (7)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- membrane protein intracellular domain proteolysis [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [IGI]
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [IGI]
- small molecule metabolic process [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
TOMM22
1C9-2, MST065, MSTP065, TOM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
GO Process (3)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Mapping the Genetic Landscape of Human Cells.
Seminal yeast studies have established the value of comprehensively mapping genetic interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets underscore the utility of this approach, but the feasibility of generating large-scale, diverse human GI maps remains unresolved. We developed a CRISPR interference platform for large-scale quantitative mapping of human GIs. We systematically perturbed 222,784 ... [more]
Cell Jul. 17, 2018; (); [Pubmed: 30033366]
Quantitative Score
- -3.490724332 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507)
- cell type: jurkat cell (BTO:0000661)
Additional Notes
- CRISPR GI screen
- Cell Line: K562 EFO:0002067/Jurkat EFO:0002796
- Experimental Setup: Timecourse
- GIST: A-phenotypic negative/positive genetic interaction
- Interactions in this CRISPR interference (CRISPRi) analysis were considered to be significant when GI <= -3 (negative genetic interaction) or GI >= 3 (positive genetic interaction).
- Jurkat cell line Replicate Average GI score = -3.490724332
- Library: CRISPRi v1
- Significance Threshold: (positive genetic interaction) 3
Curated By
- BioGRID