APC
Gene Ontology Biological Process
- T cell differentiation in thymus [ISO]
- Wnt signaling pathway [ISO]
- anterior/posterior pattern specification [ISO]
- axis specification [ISO]
- axonogenesis [ISO]
- canonical Wnt signaling pathway [ISO]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [ISO]
- cell cycle arrest [ISO, ISS]
- cell migration [ISO, ISS]
- cellular response to DNA damage stimulus [ISO, ISS]
- cellular response to nerve growth factor stimulus [IEP]
- chromosome organization [ISO]
- cytoplasmic microtubule organization [ISO]
- dorsal/ventral pattern formation [ISO]
- establishment or maintenance of cell polarity [IDA]
- hair follicle development [ISO]
- kidney development [ISO]
- metaphase/anaphase transition of mitotic cell cycle [ISO]
- mitotic cytokinesis [ISO]
- mitotic spindle assembly checkpoint [ISO]
- muscle cell cellular homeostasis [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of Wnt signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [ISO, ISS]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial cell proliferation involved in prostate gland development [ISO]
- negative regulation of microtubule depolymerization [ISO, ISS]
- negative regulation of odontogenesis [ISO]
- neuron projection development [IMP]
- pancreas development [IEP]
- pattern specification process [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell division [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of epithelial cell differentiation [ISO]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of pseudopodium assembly [ISO]
- protein complex assembly [ISO, ISS]
- proximal/distal pattern formation [ISO]
- regulation of attachment of spindle microtubules to kinetochore [ISO]
- regulation of cell cycle [ISO]
- regulation of cell differentiation [ISO]
- regulation of cell migration [ISO]
- regulation of epithelial cell differentiation [ISO]
- regulation of glutamate metabolic process [IDA]
- regulation of microtubule-based process [ISO, ISS]
- regulation of nitrogen compound metabolic process [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of osteoclast differentiation [ISO]
- response to alcohol [IEP]
- response to drug [IEP]
- retina development in camera-type eye [ISO]
- skin development [ISO]
- somatic stem cell maintenance [ISO]
- stem cell maintenance [ISO]
- thymus development [ISO]
Gene Ontology Molecular Function- beta-catenin binding [ISO, ISS]
- cadherin binding [ISO]
- gamma-catenin binding [ISO]
- microtubule binding [IDA, IMP, ISO, ISS]
- microtubule plus-end binding [ISO, ISS]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISO]
- protein kinase regulator activity [ISO, ISS]
- beta-catenin binding [ISO, ISS]
- cadherin binding [ISO]
- gamma-catenin binding [ISO]
- microtubule binding [IDA, IMP, ISO, ISS]
- microtubule plus-end binding [ISO, ISS]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISO]
- protein kinase regulator activity [ISO, ISS]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [ISO]
- axon [ISO]
- axonal growth cone [IDA, ISO]
- beta-catenin destruction complex [ISO, ISS]
- cell [ISO]
- cell body fiber [IDA]
- cell cortex [IDA]
- cell projection [ISO]
- cell projection membrane [ISO]
- cell-cell adherens junction [ISO, ISS]
- centrosome [ISO, ISS]
- cytoplasm [IDA, ISO, ISS]
- cytoplasmic microtubule [ISO]
- dendrite [IDA]
- growth cone [IDA, ISO]
- kinetochore [ISO, ISS]
- lamellipodium [IDA, ISO, ISS]
- lateral plasma membrane [ISO]
- microtubule [IDA]
- microtubule plus-end [ISO]
- neuron projection [IDA]
- neuron projection terminus [IDA]
- neuronal cell body [IDA]
- nuclear membrane [IDA]
- nucleus [IDA, ISO, ISS]
- plasma membrane [ISO, ISS]
- protein complex [IDA]
- ruffle membrane [ISO, ISS]
- synapse [IDA]
- tight junction [ISO]
PTPN13
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain.
Mutations of the tumor suppressor protein APC (Adenomatous Polyposis Coli) are linked to familiar and sporadic human colon cancer. Here we describe a novel interaction between the APC protein and the protein tyrosine phosphatase PTP-BL carrying five PDZ protein-protein interaction domains. Exclusively, the second PDZ domain (PDZ2) of PTP-BL is binding to the extreme C-terminus of the APC protein, as ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPN13 APC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| APC PTPN13 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID