TGFBR3
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell proliferation [ISS]
- cell growth [ISS]
- cell migration [ISS]
- definitive erythrocyte differentiation [ISS]
- definitive hemopoiesis [ISS]
- epithelial to mesenchymal transition [IDA]
- heart morphogenesis [ISS]
- heart trabecula formation [ISS]
- immune response [IMP]
- intracellular signal transduction [IMP]
- liver development [ISS]
- negative regulation of cellular component movement [IDA]
- negative regulation of epithelial cell proliferation [ISS]
- palate development [ISS]
- pathway-restricted SMAD protein phosphorylation [IMP]
- response to follicle-stimulating hormone [IDA]
- response to luteinizing hormone [IDA]
- response to prostaglandin E [IDA]
- transforming growth factor beta receptor signaling pathway [IDA, IMP]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function- PDZ domain binding [ISS]
- SMAD binding [IMP]
- coreceptor activity [IDA]
- glycosaminoglycan binding [ISS, TAS]
- heparin binding [ISS]
- protein binding [IPI]
- transforming growth factor beta binding [IDA]
- transforming growth factor beta receptor activity, type III [IDA]
- transforming growth factor beta receptor binding [ISS]
- transforming growth factor beta-activated receptor activity [IDA]
- type II transforming growth factor beta receptor binding [IDA]
- PDZ domain binding [ISS]
- SMAD binding [IMP]
- coreceptor activity [IDA]
- glycosaminoglycan binding [ISS, TAS]
- heparin binding [ISS]
- protein binding [IPI]
- transforming growth factor beta binding [IDA]
- transforming growth factor beta receptor activity, type III [IDA]
- transforming growth factor beta receptor binding [ISS]
- transforming growth factor beta-activated receptor activity [IDA]
- type II transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
FGFR1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- axon guidance [TAS]
- cell migration [TAS]
- chordate embryonic development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neuron migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IDA, IGI, IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of phospholipase activity [TAS]
- protein autophosphorylation [IDA]
- protein phosphorylation [NAS]
- regulation of cell differentiation [TAS]
- skeletal system development [TAS]
- skeletal system morphogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.
Growth factors and their receptors coordinate neuronal differentiation during development, yet their roles in the pediatric tumor neuroblastoma remain unclear. Comparison of mRNA from benign neuroblastic tumors and neuroblastomas revealed that expression of the type III TGF-β receptor (TGFBR3) decreases with advancing stage of neuroblastoma and this loss correlates with a poorer prognosis. Patients with MYCN oncogene amplification and low ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: nb-2 cell (BTO:0003056)
Curated By
- BioGRID