BAIT

BTAF1

MOT1, TAF(II)170, TAF172, TAFII170
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
GO Process (2)
GO Function (1)
GO Component (0)
Homo sapiens

Co-purification

An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.

Publication

BRCA1 is a component of the RNA polymerase II holoenzyme.

Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD

The familial breast-ovarian tumor suppressor gene product BRCA1 was found to be a component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to copurify with the holoenzyme over multiple chromatographic steps. Other tested transcription activators that could potentially contact the holoenzyme were not stably associated with the holoenzyme as determined by copurification. Antibody specific for the ... [more]

Proc. Natl. Acad. Sci. U.S.A. May. 27, 1997; 94(11);5605-10 [Pubmed: 9159119]

Throughput

  • Low Throughput

Curated By

  • BioGRID