BAIT
HIF1A
AA959795, HIF1alpha, MOP1, bHLHe78
hypoxia inducible factor 1, alpha subunit
GO Process (75)
GO Function (18)
GO Component (8)
Gene Ontology Biological Process
- B-1 B cell homeostasis [IMP]
- angiogenesis [IMP]
- axon transport of mitochondrion [ISO]
- blood vessel development [IMP]
- blood vessel morphogenesis [IMP]
- cardiac ventricle morphogenesis [IMP]
- cartilage development [IMP]
- cell differentiation [IGI, IMP]
- cellular iron ion homeostasis [IMP]
- cellular response to hypoxia [IGI, ISO]
- cerebral cortex development [IMP]
- collagen metabolic process [IMP]
- connective tissue replacement involved in inflammatory response wound healing [IMP]
- digestive tract morphogenesis [IMP]
- dopaminergic neuron differentiation [IGI, IMP]
- elastin metabolic process [IMP]
- embryonic hemopoiesis [IMP]
- embryonic placenta development [IGI, IMP]
- epithelial cell differentiation involved in mammary gland alveolus development [IMP]
- epithelial to mesenchymal transition [IMP]
- glucose homeostasis [IMP]
- heart looping [IMP]
- hemoglobin biosynthetic process [IMP]
- hypoxia-inducible factor-1alpha signaling pathway [IDA]
- intestinal epithelial cell maturation [IMP]
- lactate metabolic process [IMP]
- lactation [IMP]
- muscle cell cellular homeostasis [IMP]
- negative regulation of TOR signaling [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [IMP]
- negative regulation of growth [IMP]
- negative regulation of mesenchymal cell apoptotic process [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- negative regulation of thymocyte apoptotic process [IMP]
- negative regulation of transcription elongation from RNA polymerase II promoter [ISO]
- negative regulation of vasoconstriction [ISO]
- neural crest cell migration [IMP]
- neural fold elevation formation [IMP]
- outflow tract morphogenesis [IMP]
- oxygen homeostasis [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of neuroblast proliferation [IGI]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of catalytic activity [IMP]
- regulation of cell proliferation [IMP]
- regulation of gene expression [ISO]
- regulation of glycolytic process [IGI]
- regulation of thymocyte apoptotic process [IGI]
- regulation of transcription from RNA polymerase II promoter [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP, ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transforming growth factor beta2 production [ISO]
- response to fungicide [ISO]
- response to hypoxia [IDA, IGI, IMP, ISO]
- response to muscle activity [IMP]
- retina vasculature development in camera-type eye [IMP]
- signal transduction [ISO]
- transcription from RNA polymerase II promoter [IPI]
- vascular endothelial growth factor production [ISO]
- vasculature development [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, IGI]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA, IGI]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [IPI]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Mus musculus
PREY
ARNT
D3Ertd557e, Drnt, ESTM42, Hif1b, W08714, bHLHe2, mKIAA4051
aryl hydrocarbon receptor nuclear translocator
GO Process (13)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cell differentiation [IMP]
- embryonic placenta development [IMP]
- intracellular receptor signaling pathway [IMP]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of protein sumoylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of nucleic acid-templated transcription [IPI]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- regulation of transcription, DNA-templated [TAS]
- response to hypoxia [IDA, ISO]
- response to toxic substance [TAS]
Gene Ontology Molecular Function- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IGI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- aryl hydrocarbon receptor activity [IMP]
- aryl hydrocarbon receptor binding [ISO]
- enhancer binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [IPI]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) and the intracellular dioxin receptor mediate hypoxia and dioxin signalling, respectively. Both proteins are conditionally regulated basic helix-loop-helix (bHLH) transcription factors that, in addition to the bHLH motif, share a Per-Arnt-Sim (PAS) region of homology and form heterodimeric complexes with the common bHLH/PAS partner factor Arnt. Here we demonstrate that HIF-1 alpha required Arnt ... [more]
Mol. Cell. Biol. Oct. 01, 1996; 16(10);5221-31 [Pubmed: 8816435]
Throughput
- Low Throughput
Additional Notes
- Electrophoretic mobility shift assay
Curated By
- BioGRID