BAIT
CPEB2
CPE-BP2, CPEB-2, hCPEB-2
cytoplasmic polyadenylation element binding protein 2
GO Process (7)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- cellular response to arsenic-containing substance [ISS]
- cellular response to hypoxia [IDA]
- cellular response to insulin stimulus [IDA]
- cellular response to oxidative stress [ISS]
- negative regulation of GTPase activity [ISS]
- negative regulation of cytoplasmic translation [IMP]
- negative regulation of cytoplasmic translational elongation [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
COPS7A
CSN7, CSN7A, SGN7a
COP9 signalosome subunit 7A
GO Process (1)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
CPEB2-eEF2 interaction impedes HIF-1α RNA translation.
Translation of mRNA into protein proceeds in three phases: initiation, elongation, and termination. Regulated translation allows the prompt production of selective proteins in response to physiological needs and is often controlled by sequence-specific RNA-binding proteins that function at initiation. Whether the elongation phase of translation can be modulated individually by trans-acting factors to synthesize polypeptides at variable rates remains to ... [more]
EMBO J. Feb. 15, 2012; 31(4);959-71 [Pubmed: 22157746]
Throughput
- Low Throughput
Curated By
- BioGRID