BAIT
ACLY
ACL, ATPCL, CLATP
ATP citrate lyase
GO Process (10)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [TAS]
- cellular lipid metabolic process [TAS]
- citrate metabolic process [TAS]
- coenzyme A metabolic process [TAS]
- energy reserve metabolic process [TAS]
- lipid biosynthetic process [IDA]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- positive regulation of cellular metabolic process [TAS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MCM7
CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104
minichromosome maintenance complex component 7
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.
Increased lipid synthesis is a key characteristic of many cancers that is critical for cancer progression. ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, is frequently overexpressed or activated in cancer to promote lipid synthesis and tumor progression. Cullin3 (CUL3), a core protein for the CUL3-RING ubiquitin ligase complex, has been reported to be a tumor suppressor and frequently ... [more]
Genes Dev. Sep. 01, 2016; 30(17);1956-70 [Pubmed: 27664236]
Throughput
- Low Throughput
Curated By
- BioGRID