BAIT

PJA1

PRAJA1, RNF70, RP13-55H22.1
praja ring finger 1, E3 ubiquitin protein ligase
UPS Project
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens
PREY

ABR

MDB
active BCR-related
Homo sapiens

Biochemical Activity (Ubiquitination)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Protein microarrays for the identification of praja1 e3 ubiquitin ligase substrates.

Loch CM, Eddins MJ, Strickler JE

Although they are the primary determinants of substrate specificity, few E3-substrate pairs have been positively identified, and few E3's profiled in a proteomic fashion. Praja1 is an E3 implicated in bone development and highly expressed in brain. Although it has been well studied relative to the majority of E3's, little is known concerning the repertoire of proteins it ubiquitylates. We ... [more]

Cell Biochem. Biophys. Jun. 01, 2011; 60(1);127-35 [Pubmed: 21461837]

Throughput

  • High Throughput

Additional Notes

  • Source of PRAJA1 not clear.

Curated By

  • BioGRID