DNA repair protein Rad60
GO Process (4)
GO Function (1)
GO Component (1)
Schizosaccharomyces pombe (972h)


mms4, slx2, SPAPB1E7.06c
Holliday junction resolvase subunit Eme1
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association.

Raffa GD, Wohlschlegel J, Yates JR, Boddy MN

In fission yeast, the replication checkpoint is enforced by the kinase Cds1 (human Chk2), which regulates both cell cycle progression and DNA repair factors to ensure that the genome is faithfully duplicated prior to mitosis. Cds1 contains a forkhead-associated domain that mediates its interaction with phosphorylated residues in target proteins. One target of Cds1 is the essential nuclear protein Rad60, ... [more]

J. Biol. Chem. Sep. 22, 2006; 281(38);27973-81 [Pubmed: 16880212]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID