BAIT
ZNF598
zinc finger protein 598
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
CADM1
BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1
cell adhesion molecule 1
GO Process (12)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- T cell mediated cytotoxicity [IDA]
- activated T cell proliferation [IDA]
- adherens junction organization [TAS]
- cell junction assembly [TAS]
- cell recognition [IDA, ISS]
- cell-cell junction organization [TAS]
- detection of stimulus [IDA, ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISS]
- positive regulation of cytokine secretion [IDA]
- positive regulation of natural killer cell mediated cytotoxicity [IDA, ISS]
- susceptibility to natural killer cell mediated cytotoxicity [IDA, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.
Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated quality control (RQC), followed by degradation of the aberrant mRNA and polypeptide, ribosome disassembly and recycling. Although ribosomal subunit dissociation and nascent peptide degradation are well-understood, the molecular sensors of aberrant mRNAs and their mechanism of action remain unknown. We studied the Zinc Finger Protein 598 (ZNF598) using PAR-CLIP and revealed that ... [more]
Nat Commun Jul. 07, 2017; 8();16056 [Pubmed: 28685749]
Throughput
- High Throughput
Curated By
- BioGRID