BAIT
CHS2
SPBC1734.17, SPBC1709.01
chitin synthase homolog Chs2
GO Process (0)
GO Function (2)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
CDC15
SPAC20G8.05c
extended Fer/CIP4 (EFC) domain protein Cdc15
GO Process (7)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- cortical actin cytoskeleton organization [IMP]
- establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site [IMP]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic actomyosin contractile ring localization [IMP]
- protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly [IMP]
- regulation of actin nucleation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The fission yeast Chs2 protein interacts with the type-II myosin Myo3p and is required for the integrity of the actomyosin ring.
In Schizosaccharomyces pombe cytokinesis requires the function of a contractile actomyosin ring. Fission yeast Chs2p is a transmembrane protein structurally similar to chitin synthases that lacks such enzymatic activity. Chs2p localisation and assembly into a ring that contracts during division requires the general system for polarised secretion, some components of the actomyosin ring, and an active septation initiation network. Chs2p ... [more]
J. Cell. Sci. Jul. 01, 2006; 119(0);2768-79 [Pubmed: 16772338]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID