BAIT
KCTD12
C13orf2, PFET1, PFETIN
potassium channel tetramerization domain containing 12
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SET
2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, TAF-I, TAF-IBETA, RP11-216B9.3
SET nuclear proto-oncogene
GO Process (12)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- DNA replication [TAS]
- RNA metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of catalytic activity [TAS]
- negative regulation of histone acetylation [TAS]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of transcription, DNA-templated [IDA]
- nucleocytoplasmic transport [NAS]
- nucleosome disassembly [TAS]
- regulation of catalytic activity [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Cell cycle dysregulation leads to uncontrolled cell proliferation and tumorigenesis. Understanding the molecular mechanisms underlying cell cycle progression can provide clues leading to the identification of key proteins involved in cancer development. In this study, we performed proteomics analysis to identify novel regulators of the cell cycle. We found that potassium channel tetramerization domain containing 12 (KCTD12) was significantly upregulated ... [more]
Oncogene Dec. 02, 2016; 36(44);6177-6189 [Pubmed: 28869606]
Throughput
- High Throughput
Curated By
- BioGRID