BAIT
KCTD12
C13orf2, PFET1, PFETIN
potassium channel tetramerization domain containing 12
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GSTM3
GST5, GSTB, GSTM3-3, GTM3, RP4-735C1.2
glutathione S-transferase mu 3 (brain)
GO Process (9)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cellular detoxification of nitrogen compound [IDA]
- establishment of blood-nerve barrier [TAS]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [IDA]
- nitrobenzene metabolic process [IDA]
- response to estrogen [IEP]
- small molecule metabolic process [TAS]
- xenobiotic catabolic process [IDA]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Cell cycle dysregulation leads to uncontrolled cell proliferation and tumorigenesis. Understanding the molecular mechanisms underlying cell cycle progression can provide clues leading to the identification of key proteins involved in cancer development. In this study, we performed proteomics analysis to identify novel regulators of the cell cycle. We found that potassium channel tetramerization domain containing 12 (KCTD12) was significantly upregulated ... [more]
Oncogene Dec. 02, 2016; 36(44);6177-6189 [Pubmed: 28869606]
Throughput
- High Throughput
Curated By
- BioGRID