BAIT
PEA15
HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, RP11-536C5.8
phosphoprotein enriched in astrocytes 15
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP1B3
ATPB-3, CD298
ATPase, Na+/K+ transporting, beta 3 polypeptide
GO Process (17)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cellular potassium ion homeostasis [IDA]
- cellular sodium ion homeostasis [IDA]
- ion transmembrane transport [TAS]
- leukocyte migration [TAS]
- membrane repolarization [IDA]
- positive regulation of ATP catabolic process [IDA]
- positive regulation of ATPase activity [IDA]
- positive regulation of potassium ion import [IDA]
- positive regulation of potassium ion transmembrane transporter activity [IDA]
- positive regulation of sodium ion export from cell [IDA]
- potassium ion import [IDA]
- protein localization to plasma membrane [IDA]
- protein stabilization [IDA]
- sodium ion export from cell [IDA]
- transmembrane transport [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.
Regulation of the DNA damage response and cell cycle progression is critical for maintaining genome integrity. Here, we report that in response to DNA damage, COPS5 deubiquitinates and stabilizes PEA15 in an ATM kinase-dependent manner. PEA15 expression oscillates throughout the cell cycle, and the loss of PEA15 accelerates cell cycle progression by activating CDK6 expression via the c-JUN transcription factor. ... [more]
Mol. Cell. Biol. Jun. 01, 2014; 34(12);2264-82 [Pubmed: 24710276]
Throughput
- High Throughput
Curated By
- BioGRID