BAIT

PEA15

HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, RP11-536C5.8
phosphoprotein enriched in astrocytes 15
GO Process (3)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

PUS3

2610020J05Rik, FKSG32
pseudouridylate synthase 3
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation.

Nagarajan A, Dogra SK, Liu AY, Green MR, Wajapeyee N

Regulation of the DNA damage response and cell cycle progression is critical for maintaining genome integrity. Here, we report that in response to DNA damage, COPS5 deubiquitinates and stabilizes PEA15 in an ATM kinase-dependent manner. PEA15 expression oscillates throughout the cell cycle, and the loss of PEA15 accelerates cell cycle progression by activating CDK6 expression via the c-JUN transcription factor. ... [more]

Mol. Cell. Biol. Jun. 01, 2014; 34(12);2264-82 [Pubmed: 24710276]

Throughput

  • High Throughput

Curated By

  • BioGRID