HIF1AN
Gene Ontology Biological Process
- cellular response to hypoxia [TAS]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- oxidation-reduction process [IDA]
- peptidyl-asparagine hydroxylation [IDA, IMP]
- peptidyl-aspartic acid hydroxylation [IDA]
- peptidyl-histidine hydroxylation [IDA]
- positive regulation of myoblast differentiation [IDA]
- positive regulation of vasculogenesis [NAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
Gene Ontology Molecular Function- NF-kappaB binding [IPI]
- Notch binding [IPI]
- ankyrin repeat binding [IPI]
- carboxylic acid binding [IDA]
- cofactor binding [IDA]
- iron ion binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [EXP]
- oxygen sensor activity [NAS]
- peptidyl-asparagine 3-dioxygenase activity [IDA, IMP]
- peptidyl-histidine dioxygenase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [IDA]
- NF-kappaB binding [IPI]
- Notch binding [IPI]
- ankyrin repeat binding [IPI]
- carboxylic acid binding [IDA]
- cofactor binding [IDA]
- iron ion binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [EXP]
- oxygen sensor activity [NAS]
- peptidyl-asparagine 3-dioxygenase activity [IDA, IMP]
- peptidyl-histidine dioxygenase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
VHL
Gene Ontology Biological Process
- cell morphogenesis [NAS]
- cellular response to hypoxia [TAS]
- negative regulation of apoptotic process [NAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- positive regulation of cell differentiation [NAS]
- positive regulation of transcription, DNA-templated [IMP]
- protein stabilization [NAS]
- protein ubiquitination [IDA, IMP]
- proteolysis [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1.
Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor regulating cellular responses to hypoxia and is composed of alpha and beta subunits. During normoxia, factor inhibiting HIF-1 (FIH-1) inhibits the activity of HIF-1 by preventing HIF-1alpha binding to p300/CBP via modification of the Asn(803) residue. However, it is not known whether FIH-1 activity can be regulated in an oxygen-independent manner. In ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HIF1AN VHL | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 262357 | |
| VHL HIF1AN | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 262360 |
Curated By
- BioGRID